Syphilis is a sexually transmitted contamination caused by the spirochete Treponema pallidum, invasive bacterium able to crossing the placental barrier, main to congenital syphilis from an inflamed mom at some stage in any Stade of a pregnancy. Congenital syphilis is a first-rate public health problem in developing countries, but also inside the West in populations where there's little or no tracking of pregnant ladies [2]. The occurrence of congenital syphilis seems to be reducing in several international locations with the introduction of preventive prenatal screening advocated by way of the WHO, all through being pregnant, its miles related to premature delivery, spontaneous abortion, stillbirth, nonimmune hydrops, perinatal dying [3]. CS is split into early and late ailment primarily based on consequences that seem earlier than or after the age of two years. Early CS is typically present in the neo-natal period within the first four to 8 weeks. more than half (60–90%) of liveborn babies are asymptomatic at beginning, with first clinical signs supplying with the aid of the age of 3 months [4]. Mucocutaneous lesions are outstanding manifestations that arise in 40–60%, it manifests with the aid of a maculopapular rash which turns into copper-colored with desquamation basically inside the hands and soles, a bullous rash known as syphilitic pemphigus might also expand with peeling and in all likelihood scabs and wrinkles within the pores and skin. Rhinitis (“snuffles”), a nasal discharge that is first of all watery however may come to be thick, purulent, and blood tinged. rarely, cracking of the lips covered with scabs, plaques of the tongue and palate as well as white, flat, moist, raised patches known as condylomata lata inside the perioral and perianal regions [5]. different medical findings may additionally consist of hepatomegaly lymphadenopathy, pneumonia, anemia, thrombocytopenia, osteochondritis, and pseudoparalysis [2]. Ocular findings (chorioretinitis, cataract, glaucoma, and uveitis), gastrointestinal tract leading to malabsorption and diarrhea. The prognosis of congenital syphilis is mounted by means of the commentary of spirochetes in frame fluids or tissue and cautioned by using serologic take a look at consequences Non treponemal testing must be carried out on all babies with suspected CS and ought to involve the identical nontreponemal take a look at completed on the mom for direct assessment. A 4-fold difference inside the mom as opposed to toddler titers is suggestive of CS [2]. mind damage is observed in 50% of likely or showed instances of congenital syphilis, justifying the systematic overall performance of LP. on this context, on the lookout for a neuro syphilis [3], techniques and definitions tend to vary across the world. some countries rely upon a 4-fold boom in IgM titers to diagnose congenital syphilis [5]. The remedy is based on penicillin G Intra-venous 150,000 U/kg/day (in 6 doses each 4 hours) for 10 days (14 days if neurosyphilis) [3]. studies efforts are urgently needed to investigate whether or not different antibiotics inclusive of ampicillin can effectively treat congenital syphilis on kids with history of penicillin allergic reaction or in international locations wherein penis G is not available, currently, there has been an acute scarcity of penicillin.