Hemangiomas are benign tumors of thinwalled blood vessels, they are common in infants, and commonly present on the face and scalp, usually spontaneously egressing, and in the adult, they can occur anywhere on the skin. Research has suggested a possible role for estrogen as a mediator for vascular proliferation and hemangioma formation. According to estrogen and progesterone are significantly elevated during pregnancy, this may potentially explain the rapid growth of this lady’s hemangioma and the chronic DIC during her pregnancy. As for this patient, the enlarged hemangioma during pregnancy than before may due to the hormonal changes. So, for patient with hemangiomas, closely monitor during and after pregnancy is essential in planning optimal therapy and preventing morbidity for both mother and fetus.

Disseminated Intravascular Coagulation (DIC) is a condition characterized by the systemic intravascular activation of blood coagulation. Intravascular fibrin clots are formed, leading to the thrombotic obstruction of small- and midsized vessels. Furthermore, DIC can result in compromised blood supplies to organs and can contribute to multiple organ failure. DIC is divided into acute type and chronic type. There is no clear classification standard between them. DIC are classified as chronic if their performance is prolonged for more than a week or even several months. According to the laboratory examination, the acute type usually presents typical wasting coagulation disorder with obvious bleeding symptoms. However, the chronic type often had no consumption signs, but increased coagulation factors. The pathological process of DIC has been estimated to occur in up to 30% to 50% of cases of severe sepsis, which is the most common cause of DIC. Up to 20% of patients with metastasized adenocarcinoma or lymphoproliferative disease also suffer from DIC. The third cause of DIC is trauma, pancreatitis, malignancy, liver disease, giant hemangioma. Due to a large amount of blood congestion, blood stasis in hemangioma patients, primary DIC could be induced. In this case of the patients, she felt a swelling in her left upper limb and the hemangioma in pregnancy was significantly larger than before, without ecchymosis and bleeding tendency. Hormonal and vascular changes of pregnancy may exacerbate hemangiomas and coagulation function change. Patients with multiple cutaneous hemangioma should be closely monitored during and after pregnancy as increased incidence of DIC during pregnancy.

To the best of our knowledge, we could not find any other similar cases in the literature. In this case, although the hemangioma was large, it was confirmed after delivery that no fetal growth restriction, fetal malformation and other complications were caused after active anticoagulant treatment. It can be seen that hemangioma with DIC is not an absolute indication of cesarean section. Once hemangioma complicated with DIC was found, active anticoagulation should be carried out under close monitoring. If the mother and child were in good condition, pregnancy can be continued under close observation. But The choice of delivery method for such patients is still controversial.