Psoriasis is a model of chronic systemic inflammatory process on its moderate-to-severe and severe forms, the serious repercussions on the quality of life and social and work performance [8].

Considering the valuable indicator of co-morbidities of psoriasis, the restriction of its knowledge among to clinical dermatologists is astonishing. The absence of minimum skills to face cardiovascular, metabolic, and psychiatric complications. Co-morbidities are usually under diagnosed and frequently progress and worsen without adequate treatment [11]. These flaws underwent a progressive and deep change over time. Psoriasis is no longer considered an almost strictly dermatological disease. It was treated with different topics (many of them were of popular tradition, smelly, and overlapped with the discomfort of pearly flaking and repulsive-looking plaques) until it was revealed as a systemic disease of cardiovascular, metabolic, psychiatric, and/or psychosomatic involvement, especially in moderate-to-severe and severe presentations [6,9]. The systemic, restricted, and tightly controlled treatment (methotrexate, cyclosporine, and acitretin) was insufficient to completely alleviate the discouragement. However, it became promising (with due reservations), returning to a full social life for people with access to first-line drugs, the so-called biological products [1,2]. The concept of systemic inflammatory disease began to spread internationally and specialists from related areas have become familiar with the relationships between psoriasis and risky pathological states: diabetes, hypertension, hyper-lipidemia, cardiovascular diseases, oral diseases, distress, anxiety, depression, sleep disorders, sexual dysfunctions, alcoholism, and drug abuse [3,4]. It’s important to recognize the general suffering experienced by women, including more intense than in men in the same condition and women with equally important illnesses [5]. The dysfunctional metabolic conditions (dyslipidemia, obesity, and diabetes), women with psoriasis are more subject to drug addiction when discouragement and the difficulty of containing the disease outweigh the positive aspects of their behavior (women have greater chance of adhering to treatments in comparison to men). Feelings of isolation, humiliation, and disgust underlie the deterioration in the mental health of women who face deformation of self-image and loss of the will to live. Social and family losses can result from the lack of receptivity for these women by structures that should identify the critical situation and build satisfactory viable solutions [2]. The psychological damage associated with psoriasis in its moderate and severe forms is related to damage intensity, which can lead to despair and suicidal ideation. Psoriasis has also come to induce serious psychosomatic and somatic disorders that feed on themselves [13]. Data were incisive and decisive regarding the systemic risks that harm the quality of life and the importance of the mental health of women with psoriasis in any age and hormonal (procreative or not) range. Thus, the importance of dermatologists is crucial, but their experiences do not reach the skills of endocrinologists (diabetes and nutrition), cardiologists (myocardial infarction, arterial hypertension, and hyperlipidemia), and psychologists and/or psychiatrists (stress, depression, suicidal ideation, and tendency to alcoholism), but have to made the difference [10]. Specialists must to consider psoriasis as a public health with an important risk marker of general health and psychophysical well-being aspects that should be considered in women's health programs. There is little doubt that women are an appreciable contingent of people subjected to a greater burden of suffering in comparison to other injuries of the same dimension, but not visible, not externalized to public judgment in everyday life and not subject to daily scrutiny with all consequent stress overloaded [13].